ea0033p24 | (1) | BSPED2013
Arya Ved Bhushan
, Heslegrave Amanda
, Shah Pratik
, Gilbert Clare
, Morgan Kate
, Hinchey Louise
, Flanagan Sarah E.
, Ellard Sian
, Hussain Khalid
Introduction: Hyperinsulinaemic hypoglycaemia (HH), characterized by unregulated insulin secretion from pancreatic β-cells, is an important cause of hypoglycaemia in children. Mutations in the KATP channel genes (ABCC8/KCNJ11) are the most common cause of congenital HH. The second common cause, hyperinsulinism hyperammonaemia (HIHA) syndrome caused by mutations in GLUD1 gene, is associated with elevated serum ammonia and protein sensitivity. W...